Neurobiology of Disease Mitochondrial-Dependent Ca Handling in Huntington’s Disease Striatal Cells: Effect of Histone Deacetylase Inhibitors
نویسندگان
چکیده
Jorge M. A. Oliveira,1,2,4 Sylvia Chen,2 Sandra Almeida,4 Rebeccah Riley,2 Jorge Gonçalves,1 Catarina R. Oliveira,4 Michael R. Hayden,3 David G. Nicholls,2 Lisa M. Ellerby,2 and A. Cristina Rego4 1Serviço de Farmacologia da Faculdade de Farmácia, Centro de Estudos de Quı́mica Orgânica, Fitoquı́mica e Farmacologia, Universidade do Porto, 4050047 Porto, Portugal, 2Buck Institute for Age Research, Novato, California 94945, 3Department of Medical Genetics, Center for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4, and 4Center for Neuroscience and Cell Biology and Faculty of Medicine, University of Coimbra, 3004-504 Coimbra, Portugal
منابع مشابه
Striatal dopamine levels and changes in mitochondrial function following chronic 3-nitropropionic acid treatment in rats
An irreversible inhibitor of complex II in the mitochondria, 3-nitropropionic acid (3-NP), induces bilateral striatal lesions with many neuropathological features of Huntington’s disease (HD) in rats. It is widely used as a model of HD. Chronic systemic treatment of 3-NP for 4 days in rats (10, 15 and 20 mg/kg) caused a significant dose-dependent reduction in succinate dehydrogenase activity, w...
متن کاملStriatal dopamine levels and changes in mitochondrial function following chronic 3-nitropropionic acid treatment in rats
An irreversible inhibitor of complex II in the mitochondria, 3-nitropropionic acid (3-NP), induces bilateral striatal lesions with many neuropathological features of Huntington’s disease (HD) in rats. It is widely used as a model of HD. Chronic systemic treatment of 3-NP for 4 days in rats (10, 15 and 20 mg/kg) caused a significant dose-dependent reduction in succinate dehydrogenase activity, w...
متن کاملSearch for the Pharmacophore of Histone Deacetylase Inhibitors Using Pharmacophore Query and Docking Study
Histone deacetylase inhibitors have gained a great deal of attention recently for the treatment of cancers and inflammatory diseases. So design of new inhibitors is of great importance in pharmaceutical industries and labs. Creating pharmacophor models in order to design new molecules or search a library for finding lead compounds is of great interest. This approach reduces the overall cost ass...
متن کاملSearch for the Pharmacophore of Histone Deacetylase Inhibitors Using Pharmacophore Query and Docking Study
Histone deacetylase inhibitors have gained a great deal of attention recently for the treatment of cancers and inflammatory diseases. So design of new inhibitors is of great importance in pharmaceutical industries and labs. Creating pharmacophor models in order to design new molecules or search a library for finding lead compounds is of great interest. This approach reduces the overall cost ass...
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